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Article

Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.

International journal of cancer - 1 Aug 2012

Lee Su-Kyung, Han Young-Min, Yun Jieun, Lee Chang Woo, Shin Dae-Seop, Ha Young-Ran, Kim Jina, Koh Jong Sung, Hong Su-Hyung, Han Dong Cho, Kwon Byoung-Mog

Abstract excerpt

Phosphatase of regenerating liver (PRL)-3, a member of a subgroup of protein tyrosine phosphatases that can stimulate the degradation of the extracellular matrix, is over-expressed in metastatic colorectal cancer (CRC) relative to primary tumors. To determine whether PRL-3-induced enhancement of migration and invasion is dependent on the expression of matrix metalloproteinases (MMPs), PRL-3 was expressed in DLD-1...

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PMID: 22131018
DOI: 10.1002/ijc.27381

Genes

PRL
DLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.PMID 22131018Read ↗

PRL phosphatases as potential molecular targets in cancerSemantic proximity Read ↗

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Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.Semantic proximity Read ↗

Phosphatase of regenerating liver: a novel target for cancer therapySemantic proximity Read ↗

Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal OncogenesisSemantic proximity Read ↗

Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2.Semantic proximity Read ↗

The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.Semantic proximity Read ↗

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