Article
Gender moderates the relationship between mania spectrum and serotonin transporter polymorphisms in depression.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2009
Rucci P, Nimgaonkar V L, Mansour H, Miniati M, Masala I, Fagiolini A, Cassano G B, Frank E
Abstract excerpt
The short (s) variant of the serotonin transporter gene linked functional polymorphic region (5-HTTLPR) is associated with depression. Stressful life events, gender, and race have been shown to moderate this association. Because features of mania/hypomania seem to constitute an indicator of higher severity of depression, we examined the relationship between 5-HTTLPR genotype and symptoms of mania-hypomania...
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