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Article

Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype.

Molecular psychiatry - 1 Aug 2011

Conejero-Goldberg C, Hyde T M, Chen S, Dreses-Werringloer U, Herman M M, Kleinman J E, Davies P, Goldberg T E

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative condition characterized histopathologically by neuritic plaques and neurofibrillary tangles. The objective of this transcriptional profiling study was to identify both neurosusceptibility and intrinsic neuroprotective factors at the molecular level, not confounded by the downstream consequences of pathology. We thus studied post-mortem cortical tissue in 28 cases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20479757
DOI: 10.1038/mp.2010.57
PMCID: PMC2953572

Genes

APOE
APP
CASP6
CNTFR
CTNNB1
EGFR
FKBPL
GRIA2
LGALS1
MAPT
PSMC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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