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Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models.

Neurobiology of aging - 1 Feb 2015

Martiskainen Henna, Viswanathan Jayashree, Nykänen Niko-Petteri, Kurki Mitja, Helisalmi Seppo, Natunen Teemu, Sarajärvi Timo, Kurkinen Kaisa M A, Pursiheimo Juha-Pekka, Rauramaa Tuomas, Alafuzoff Irina, Jääskeläinen Juha E, Leinonen Ville, Soininen Hilkka, Haapasalo Annakaisa, Huttunen Henri J, Hiltunen Mikko

Abstract excerpt

In this study, we have assessed the expression and splicing status of genes involved in the pathogenesis or affecting the risk of Alzheimer's disease (AD) in the postmortem inferior temporal cortex samples obtained from 60 subjects with varying degree of AD-related neurofibrillary pathology. These subjects were grouped based on neurofibrillary pathology into 3 groups: Braak stages 0-II, Braak stages III-IV, and...

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PMID: 25281018
DOI: 10.1016/j.neurobiolaging.2014.09.003

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TREM2
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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