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Effects of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer's disease in China: Data from the PUMCH dementia cohort.

Brain and behavior - 1 Nov 2021

Dong Liling, Li Jie, Liu Caiyan, Mao Chenhui, Wang Jie, Lei Dan, Huang Xinying, Chu Shanshan, Hou Bo, Feng Feng, Sha Longze, Xu Qi, Gao Jing

Abstract excerpt

INTRODUCTION: To investigate the heterogeneous effect of Apolipoprotein E (ApoE) genotype on clinical phenotypes in early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD), respectively. METHODS: 785 probable AD patients were enrolled from the dementia cohort of Peking Union Medical College Hospital (PUMCH), China. There were 386 EOAD and 399 LOAD cases. All individuals finished history...

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PMID: 34555265
DOI: 10.1002/brb3.2373
PMCID: PMC8613405

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Source receipt: pubmed, retrieved 7 Sept 2026.

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