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Article

Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunit.

Biophysical journal - 1 Sept 2008

Miceli Francesco, Soldovieri Maria Virginia, Hernandez Ciria C, Shapiro Mark S, Annunziato Lucio, Taglialatela Maurizio

Abstract excerpt

The K(v)7.2 subunits are the main molecular determinants of the M-current, a widespread K(+) current regulating neuronal excitability. Mutations in the K(v)7.2 gene cause benign familial neonatal seizures, an autosomally inherited human epilepsy. The benign familial neonatal seizure-causing mutations include those at arginine residues at positions 207 and 214 in the S(4) segment of K(v)7.2. In this study, each of...

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Identifiers

PMID: 18515377
DOI: 10.1529/biophysj.107.128371
PMCID: PMC2517032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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