Article
Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunit.
Biophysical journal - 1 Sept 2008
Miceli Francesco, Soldovieri Maria Virginia, Hernandez Ciria C, Shapiro Mark S, Annunziato Lucio, Taglialatela Maurizio
Abstract excerpt
The K(v)7.2 subunits are the main molecular determinants of the M-current, a widespread K(+) current regulating neuronal excitability. Mutations in the K(v)7.2 gene cause benign familial neonatal seizures, an autosomally inherited human epilepsy. The benign familial neonatal seizure-causing mutations include those at arginine residues at positions 207 and 214 in the S(4) segment of K(v)7.2. In this study, each of...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Arginine
- CHO Cells
- Cricetinae
- Cricetulus
- Electrophysiology
- Epilepsy, Benign Neonatal
- Glutamine
- Humans
- Ion Channel Gating
- KCNQ2 Potassium Channel