Article
Macrophage fatty-acid synthase deficiency decreases diet-induced atherosclerosis.
The Journal of biological chemistry - 23 Jul 2010
Schneider Jochen G, Yang Zhen, Chakravarthy Manu V, Lodhi Irfan J, Wei Xiaochao, Turk John, Semenkovich Clay F
Abstract excerpt
Fatty acid metabolism is perturbed in atherosclerotic lesions, but whether it affects lesion formation is unknown. To determine whether fatty acid synthesis affects atherosclerosis, we inactivated fatty-acid synthase (FAS) in macrophages of apoE-deficient mice. Serum lipids, body weight, and glucose metabolism were the same in FAS knock-out in macrophages (FASKOM) and control mice, but blood pressure was lower in...
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