Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.

The Journal of clinical investigation - 1 Aug 2007

Bradley Michelle N, Hong Cynthia, Chen Mingyi, Joseph Sean B, Wilpitz Damien C, Wang Xuping, Lusis Aldons J, Collins Allan, Hseuh Willa A, Collins Jon L, Tangirala Rajendra K, Tontonoz Peter

Abstract excerpt

Liver X receptors (LXRs) alpha and beta are transcriptional regulators of cholesterol homeostasis and potential targets for the development of antiatherosclerosis drugs. However, the specific roles of individual LXR isotypes in atherosclerosis and the pharmacological effects of synthetic agonists remain unclear. Previous work has shown that mice lacking LXRalpha accumulate cholesterol in the liver but not in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Cholesterol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Design

Share to Hypercholesterolemia

Share to Liver X Receptors

Share to Macrophage Activation

Share to Orphan Nuclear Receptors

Share to Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 17657314
DOI: 10.1172/JCI31909
PMCID: PMC1924496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.PMID 17657314Read ↗

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.Semantic proximity Read ↗

A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitisSemantic proximity Read ↗

Beyond the Foam Cell: The Role of LXRs in Preventing AtherogenesisSemantic proximity Read ↗

A Novel Mutation in LXRα Uncovers a Role for Cholesterol Sensing in Limiting Metabolic Dysfunction-Associated Steatohepatitis (MASH)Semantic proximity Read ↗

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophagesSemantic proximity Read ↗

Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice.Semantic proximity Read ↗

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptorsSemantic proximity Read ↗

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.Semantic proximity Read ↗

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular DiseasesSemantic proximity Read ↗

Do the Apoe-/- and Ldlr-/- Mice Yield the Same Insight on Atherogenesis?Semantic proximity Read ↗

Minireview: liver X receptor beta: emerging roles in physiology and diseases.Semantic proximity Read ↗

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.