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Article

Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expression.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2007

Vilà Laia, Roglans Núria, Alegret Marta, Camins Antoni, Pallàs Mercè, Sánchez Rosa María, Vázquez-Carrera Manuel, Laguna Juan Carlos

Abstract excerpt

Aged rodents show increasing plasma and tissue triglycerides, and reductions in liver peroxisome proliferator-activated receptor alpha (PPARalpha) and its target genes. We determined whether a similar situation is present in a model of accelerated aging, the senescence-accelerated prone (SAM-P8) mouse. Five-month-old SAM-P8 mice were hypertriglyceridemic, and exhibited hepatic steatosis and reduced fatty acid...

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Identifiers

PMID: 18000141
DOI: 10.1093/gerona/62.11.1219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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