Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The toll-like receptor 1 variant S248N influences placental malaria.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2010

Hamann Lutz, Bedu-Addo George, Eggelte Teunis A, Schumann Ralf R, Mockenhaupt Frank P

Abstract excerpt

In malaria-endemic regions, Plasmodium falciparum infection in pregnancy is a predominant cause of maternal and infant morbidity and mortality. Primiparae are relatively immune-naïve and particularly prone. Innate immune recognition of P. falciparum is partly mediated by Toll-like receptors (TLRs), and single nucleotide polymorphisms (SNPs) of TLR-4 and -9 influence manifestation. Recognition via TLR-2, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Ghana

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Malaria, Falciparum

Share to Placenta

Share to Pregnancy Complications, Parasitic

Share to Prevalence

Share to Serine

Share to Toll-Like Receptor 1

Source

Identifiers

PMID: 20478407
DOI: 10.1016/j.meegid.2010.05.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The toll-like receptor 1 variant S248N influences placental malaria.PMID 20478407Read ↗

Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy.Semantic proximity Read ↗

Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria.Semantic proximity Read ↗

Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.Semantic proximity Read ↗

Association of toll like receptors polymorphism (TLR1-rs4833095, TLR1-rs5743611, TLR6-rs5743810, TLR6-rs5743809, TLR4-rs4986790, TLR4-rs4986791, TLR9 rs187084) with clinical outcome of malaria among children in Ibadan, Southwest Nigeria.Semantic proximity Read ↗

TOLLIP gene variant is associated with Plasmodium vivax malaria in the Brazilian Amazon.Semantic proximity Read ↗

A Toll-like receptor-1 variant and its characteristic cellular phenotype is associated with severe malaria in Papua New Guinean children.Semantic proximity Read ↗

Toll-like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study.Semantic proximity Read ↗

Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana.Semantic proximity Read ↗

Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children.Semantic proximity Read ↗

Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria.Semantic proximity Read ↗

Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against placental malaria.Semantic proximity Read ↗

A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.