Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jan 2000

Zade David, Beiser Alexa, McGlinchey Regina, Au Rhoda, Seshadri Sudha, Palumbo Carole, Wolf Philip A, Decarli Charles, Milberg William

Abstract excerpt

OBJECTIVE: We sought to determine whether the presence of the apolipoprotein E type 4 (apoE4) allele, a known risk factor for Alzheimer disease, interacts with cerebrovascular risk factors to produce a disproportionate impairment in neuropsychological (NP) performance and alterations in structural morphometry as measured by magnetic resonance imaging (MRI). METHODS: In all, 1995 participants from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Brain Mapping

Share to Cerebrovascular Disorders

Share to Cognition

Share to Linear Models

Share to Neuropsychological Tests

Share to Organ Size

Source

Open in PubMed Open full text

Identifiers

PMID: 20471857
DOI: 10.1016/j.jstrokecerebrovasdis.2009.05.001
PMCID: PMC2900511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes.PMID 20471857Read ↗

Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure.Semantic proximity Read ↗

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individualsSemantic proximity Read ↗

Apolipoprotein E e4 allele in the normal elderly: neuropsychologic and brain MRI correlates.Semantic proximity Read ↗

Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment.Semantic proximity Read ↗

Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume.Semantic proximity Read ↗

Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses.Semantic proximity Read ↗

Interaction between hypertension, apoE, and cerebral white matter lesions.Semantic proximity Read ↗

Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4.Semantic proximity Read ↗

Impact of apolipoprotein E epsilon4 and vascular disease on brain morphology in men from the NHLBI twin study.Semantic proximity Read ↗

Blood pressure interacts with APOE ε4 to predict memory performance in a midlife sample.Semantic proximity Read ↗

Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults.Semantic proximity Read ↗

APOE genotype modifies the association between central arterial stiffening and cognition in older adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.