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Article

Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4.

Alzheimer disease and associated disorders - 1 Jan 2000

Nation Daniel A, Preis Sarah R, Beiser Alexa, Bangen Katherine J, Delano-Wood Lisa, Lamar Melissa, Libon David J, Seshadri Sudha, Wolf Philip A, Au Rhoda

Abstract excerpt

We investigated whether midlife pulse pressure is associated with brain atrophy and cognitive decline, and whether the association was modified by apolipoprotein-E ε4 (APOE-ε4) and hypertension. Participants (549 stroke-free and dementia-free Framingham Offspring Cohort Study participants, age range=55.0 to 64.9 y) underwent baseline neuropsychological and magnetic resonance imaging (subset, n=454) evaluations...

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Source

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Identifiers

PMID: 27556935
DOI: 10.1097/WAD.0000000000000127
PMCID: PMC4999260

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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