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Article

APOE genotype modifies the association between central arterial stiffening and cognition in older adults.

Neurobiology of aging - 1 Jul 2018

Cambronero Francis E, Liu Dandan, Neal Jacquelyn E, Moore Elizabeth E, Gifford Katherine A, Terry James G, Nair Sangeeta, Pechman Kimberly R, Osborn Katie E, Hohman Timothy J, Bell Susan P, Sweatt J David, Wang Thomas J, Beckman Joshua A, Carr John Jeffrey, Jefferson Angela L

Abstract excerpt

Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt Memory & Aging Project participants with normal cognition (n = 162, 72 ± 7 years, 29% APOE-ε4 carrier) and mild cognitive impairment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29656011
DOI: 10.1016/j.neurobiolaging.2018.02.009
PMCID: PMC5985659

Genes

APOE

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