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Article

Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Feb 2013

Zade David, Beiser Alexa, McGlinchey Regina, Au Rhoda, Seshadri Sudha, Palumbo Carole, Wolf Philip A, DeCarli Charles, Milberg William

Abstract excerpt

BACKGROUND: This study aimed to determine whether relationships between obesity, as measured by waist-to-hip ratio (WHR), and cognition and brain structure were modified by the apolipoprotein epsilon 4 allele (apoE4). METHODS: The sample included 1969 stroke- and dementia-free participants from the Framingham Offspring Cohort who underwent neuropsychological (NP) testing and structural magnetic resonance imaging...

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Identifiers

PMID: 21835633
DOI: 10.1016/j.jstrokecerebrovasdis.2011.06.020
PMCID: PMC3613758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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