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Article

Altered expression of Raet1e, a major histocompatibility complex class 1-like molecule, underlies the atherosclerosis modifier locus Ath11 10b.

Circulation research - 12 Oct 2013

Rodríguez José M, Wolfrum Susanne, Robblee Megan, Chen Kwan Y, Gilbert Zachary N, Choi Jae-Hoon, Teupser Daniel, Breslow Jan L

Abstract excerpt

RATIONALE: Quantitative trait locus mapping of an intercross between C57.Apoe⁻/⁻ and FVB.Apoe⁻/⁻ mice revealed an atherosclerosis locus controlling aortic root lesion area on proximal chromosome 10, Ath11. In a previous work, subcongenic analysis showed Ath11 to be complex with proximal (10a) and distal (10b) regions. OBJECTIVE: To identify the causative genetic variation underlying the atherosclerosis modifier...

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Identifiers

PMID: 23948654
DOI: 10.1161/CIRCRESAHA.113.302052
PMCID: PMC3938025

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