Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel strategy using F1-congenic mice for validation of QTLs: studies at the proximal chromosome 10 atherosclerosis susceptibility locus.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2009

Teupser Daniel, Wolfrum Susanne, Tan Marietta, Persky Adam D, Dansky Hayes M, Breslow Jan L

Abstract excerpt

OBJECTIVE: We have previously identified a quantitative trait locus (QTL) for atherosclerosis susceptibility on proximal chromosome 10 (Chr10) (Ath11) in independent crosses of FVB and C57BL/6 (B6) mice on the apolipoprotein E (ApoE-/-) and LDL receptor (LDLR-/-) deficient backgrounds. The aims of the current study were to (1) test a novel strategy for validating QTLs using interval-specific congenic strains that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crosses, Genetic

Share to LDLR gene

Share to Genetic Predisposition to Disease

Share to Mice, Congenic

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 19251590
DOI: 10.1161/ATVBAHA.108.179408
PMCID: PMC2738862

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel strategy using F1-congenic mice for validation of QTLs: studies at the proximal chromosome 10 atherosclerosis susceptibility locus.PMID 19251590Read ↗

The mouse atherosclerosis locus at chromosome 10 (Ath11) acts early in lesion formation with subcongenic strains delineating 2 narrowed regions.Semantic proximity Read ↗

Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on Chromosome 1.Semantic proximity Read ↗

Altered expression of Raet1e, a major histocompatibility complex class 1-like molecule, underlies the atherosclerosis modifier locus Ath11 10b.Semantic proximity Read ↗

Fine Mapping of the Mouse Ath28 Locus Yields Three Atherosclerosis Modifying Sub-Regions.Semantic proximity Read ↗

Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model.Semantic proximity Read ↗

Polygenic Control of Carotid Atherosclerosis in a BALB/cJ × SM/J Intercross and a Combined Cross Involving Multiple Mouse Strains.Semantic proximity Read ↗

Atherosclerosis susceptibility Loci identified in an extremely atherosclerosis-resistant mouse strain.Semantic proximity Read ↗

Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice.Semantic proximity Read ↗

In silico quantitative trait locus map for atherosclerosis susceptibility in apolipoprotein E-deficient mice.Semantic proximity Read ↗

Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice.Semantic proximity Read ↗

A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background.Semantic proximity Read ↗

Genetic analysis of a mouse cross implicates an anti-inflammatory gene in control of atherosclerosis susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.