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Article

The hydroxyurea-induced small GTP-binding protein SAR modulates γ-globin gene expression in human erythroid cells

29 Jun 2005

Abstract excerpt

Hydroxyurea (HU), a drug effective in the treatment of sickle cell disease, is thought to indirectly promote fetal hemoglobin (Hb F) production by perturbing the maturation of erythroid precursors. The molecular mechanisms involved in HU-mediated regulation of gamma-globin expression are currently unclear. We identified an HU-induced small guanosine triphosphate (GTP)-binding protein, secretion-associated and...

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Identifiers

PMID: 15985540
DOI: 10.1182/blood-2003-10-3458

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