delta-Globin gene structure and expression in the K562 cell line.

doi:10.1081/hem-120026046

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Article

delta-Globin gene structure and expression in the K562 cell line.

Hemoglobin - 1 Nov 2003

Poddie Daniela, Marongiu Maria F, Ferrari Silvia Cigliuti, Porcu Susanna, Ristaldi Maria S

Abstract excerpt

The delta-globin gene produces the delta chain of Hb A2 which represents less than 3% of the hemoglobin (Hb) in normal individuals. The delta-globin gene is also expressed in the human erythroleukemia cell line K562. The expression of the delta-globin gene in this cell line is unexpected since K562 shows an embryonic-fetal globin gene expression pattern with no expression of the adult beta-globin gene....

Topics

Gene Expression Regulation
Genetic Variation
Globins
Hemoglobin A2
Humans
K562 Cells
RNA, Messenger
Sequence Analysis, DNA
Transcriptional Activation

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Open in PubMed

Identifiers

PMID: 14649312
DOI: 10.1081/hem-120026046

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