Mechanism for fetal globin gene expression: Role of the soluble guanylate cyclase–cGMP-dependent protein kinase pathway

Abstract excerpt

Despite considerable concerns with pharmacological stimulation of fetal hemoglobin (Hb F) as a therapeutic option for the beta-globin disorders, the molecular basis of action of Hb F-inducing agents remains unclear. Here we show that an intracellular pathway including soluble guanylate cyclase (sGC) and cGMP-dependent protein kinase (PKG) plays a role in induced expression of the gamma-globin gene. sGC, an...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cannabis and Cannabinoid Research
• Share to Hemoglobinopathies and Related Disorders
• Share to Neonatal Health and Biochemistry