Molecular and cellular mechanisms of leukemic hemopoietic cell differentiation: an analysis of the Friend system.

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Article

Molecular and cellular mechanisms of leukemic hemopoietic cell differentiation: an analysis of the Friend system.

Anticancer research - 1 Jan 2000

Tsiftsoglou A S, Wong W

Abstract excerpt

Murine erythroleukemia (MEL or Friend) cells grown in culture and induced to differentiate into cells resembling orthochromatic normoblasts provide a suitable system for uncovering molecular and cellular mechanisms of hemopoiesis and for understanding globin gene regulation. Inducer-treated cells...

Topics

Animals
Cell Differentiation
Cell Line
Cell Membrane
Chromatin
Clone Cells
DNA, Neoplasm
Dimethyl Sulfoxide
Friend murine leukemia virus
Gene Expression Regulation
Globins
Hematopoietic Stem Cells
Hemoglobins
Humans
Leukemia, Erythroblastic, Acute
Leukemia, Experimental
Methylation
Mice

Source

Open in PubMed

Identifiers

PMID: 3888045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-3888045-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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