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Article

Molecular and cellular mechanisms of leukemic hemopoietic cell differentiation: an analysis of the Friend system.

Anticancer research - 1 Jan 2000

Tsiftsoglou A S, Wong W

Abstract excerpt

Murine erythroleukemia (MEL or Friend) cells grown in culture and induced to differentiate into cells resembling orthochromatic normoblasts provide a suitable system for uncovering molecular and cellular mechanisms of hemopoiesis and for understanding globin gene regulation. Inducer-treated cells undergo an irreversible commitment to maturation and accumulate large amounts of hemoglobin. Clonal analysis of...

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PMID: 3888045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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