Article
Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene.
Cancer research - 15 May 2010
Olshavsky Nicholas A, Comstock Clay E S, Schiewer Matthew J, Augello Michael A, Hyslop Terry, Sette Claudio, Zhang Jinsong, Parysek Linda M, Knudsen Karen E
Abstract excerpt
The cyclin D1b oncogene arises from alternative splicing of the CCND1 transcript, and harbors markedly enhanced oncogenic functions not shared by full-length cyclin D1 (cyclin D1a). Recent studies showed that cyclin D1b is selectively induced in a subset of tissues as a function of tumorigenesis; however, the underlying mechanism(s) that control tumor-specific cyclin D1b induction remain unsolved. Here, we...
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