Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The cyclin D1b splice variant: an old oncogene learns new tricks.

1 Jan 2006

Abstract excerpt

The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase, through its ability to activate cyclin dependent kinase (CDK) 4 or 6. Active CDK4/6-cyclin D1 complexes phosphorylate substrates that are critical for modulating G1 to S phase progression, and in this manner promote cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16863592
DOI: 10.1186/1747-1028-1-15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The cyclin D1b splice variant: an old oncogene learns new tricks.PMID 16863592Read ↗

Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulationSemantic proximity Read ↗

Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer.Semantic proximity Read ↗

Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation.Semantic proximity Read ↗

Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage ResponseSemantic proximity Read ↗

Aberrant Cyclin D1 splicing in cancer: from molecular mechanism to therapeutic modulation.Semantic proximity Read ↗

Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and presentSemantic proximity Read ↗

Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypesSemantic proximity Read ↗

Cyclins and Cell Cycle Control in Cancer and DiseaseSemantic proximity Read ↗

Cyclin D1b splice variant promotes αvβ3-mediated adhesion and invasive migration of breast cancer cells.Semantic proximity Read ↗

CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer TherapySemantic proximity Read ↗

Alternate Cyclin D1 mRNA Splicing Modulates p27KIP1 Binding and Cell MigrationSemantic proximity Read ↗

Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.