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Article

Increased Expression of SIM2-s Protein Is a Novel Marker of Aggressive Prostate Cancer

1 Feb 2007

Abstract excerpt

PURPOSE: The human SIM2 gene is located within the Down's syndrome critical region of chromosome 21 and encodes transcription factors involved in brain development and neuronal differentiation. SIM2 has been assigned a possible role in the pathogenesis of solid tumors, and the SIM2-short isoform (SIM2-s) was recently proposed as a molecular target for cancer therapy. We previously reported SIM2 among the highly...

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PMID: 17289882
DOI: 10.1158/1078-0432.ccr-06-1207

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