Article
Genes for human general transcription initiation factors TFIIIB, TFIIIB-associated proteins, TFIIIC2 and PTF/SNAPC: functional and positional candidates for tumour predisposition or inherited genetic diseases?
Oncogene - 9 Aug 2001
Purrello M, Di Pietro C, Rapisarda A, Amico V, Giunta V, Engel H, Stevens S, Hsieh Y, Teichman M, Wang Z, Sichel G, Roeder R, Grzeschik K H
Abstract excerpt
TFIIIB, TFIIIC2, and PTF/SNAPC are heteromultimeric general transcription factors (GTFs) needed for expression of genes encoding small cytoplasmic (scRNAs) and small nuclear RNAs (snRNAs). Their activity is stimulated by viral oncogenes, such as SV40 large T antigen and Adenovirus E1A, and is repressed by specific transcription factors (STFs) acting as anti-oncogenes, such as p53 and pRb. GTFs role as final...
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