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Article

Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation

6 Feb 2006

Abstract excerpt

Cyclin D1 is a multifaceted regulator of both transcription and cell-cycle progression that exists in two distinct isoforms, cyclin D1a and D1b. In the prostate, cyclin D1a acts through discrete mechanisms to negatively regulate androgen receptor (AR) activity and thus limit androgen-dependent proliferation. Accordingly, cyclin D1a is rarely overexpressed in prostatic adenocarcinoma and holds little prognostic...

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PMID: 16461912
DOI: 10.1073/pnas.0506281103

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