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Article

Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation.

The Journal of biological chemistry - 8 Aug 2003

Solomon David A, Wang Ying, Fox Sejal R, Lambeck Tah C, Giesting Sarah, Lan Zhengdao, Senderowicz Adrian M, Conti Claudio J, Knudsen Erik S

Abstract excerpt

Cyclin D1 is a proto-oncogene that functions by inactivation of the retinoblastoma tumor suppressor protein, RB. A common polymorphism in the cyclin D1 gene is associated with the production of an alternate transcript of cyclin D1, termed cyclin D1b. Both the polymorphism and the variant transcript are associated with increased risk for multiple cancers and the severity of a given cancer; however, the underlying...

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Identifiers

PMID: 12746453
DOI: 10.1074/jbc.M303969200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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