Article
Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2009
Comstock Clay E S, Augello Michael A, Benito Ruth Pe, Karch Jason, Tran Thai H, Utama Fransiscus E, Tindall Elizabeth A, Wang Ying, Burd Craig J, Groh Eric M, Hoang Hoa N, Giles Graham G, Severi Gianluca, Hayes Vanessa M, Henderson Brian E, Le Marchand Loic, Kolonel Laurence N, Haiman Christopher A, Baffa Raffaele, Gomella Leonard G, Knudsen Erik S, Rui Hallgeir, Henshall Susan M, Sutherland Robert L, Knudsen Karen E
Abstract excerpt
PURPOSE: Alternative CCND1 splicing results in cyclin D1b, which has specialized, protumorigenic functions in prostate not shared by the cyclin D1a (full length) isoform. Here, the frequency, tumor relevance, and mechanisms controlling cyclin D1b were challenged. EXPERIMENTAL DESIGN: First, relative expression of both cyclin D1 isoforms was determined in prostate adenocarcinomas. Second, relevance of the androgen...
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