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Article

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

11 May 2010

Abstract excerpt

Telomeres, the physical ends of eukaryotes chromosomes are transcribed into telomeric repeat containing RNA (TERRA), a large non-coding RNA of unknown function, which forms an integral part of telomeric heterochromatin. TERRA molecules resemble in sequence the telomeric DNA substrate as they contain 5'-UUAGGG-3' repeats near their 3'-end which are complementary to the template sequence of telomerase RNA. Here we...

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Share to Advanced biosensing and bioanalysis techniques
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Share to Telomeres, Telomerase, and Senescence

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PMID: 20460456
DOI: 10.1093/nar/gkq296

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The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerasePMID 20460456Read ↗

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Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short TelomeresSemantic proximity Read ↗

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TERRA long noncoding RNA: At the interphase of telomere damage, rescue and signalingSemantic proximity Read ↗

TERRA and the alternative lengthening of telomeres: a dangerous affairSemantic proximity Read ↗

In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2Semantic proximity Read ↗

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Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complexSemantic proximity Read ↗

RTEL1 influences the abundance and localization of TERRA RNASemantic proximity Read ↗

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