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Article

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

8 Aug 2013

Abstract excerpt

Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of telomeric heterochromatin. In vitro, naked TERRA molecules are efficient inhibitors of human telomerase, base-pairing via their 5'-UUAGGG-3' repeats with the template sequence of telomerase RNA, in addition to contacting the telomerase...

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Share to Chromosomal and Genetic Variations
Share to RNA regulation and disease
Share to Telomeres, Telomerase, and Senescence

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PMID: 23935072
DOI: 10.1093/nar/gkt695

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A three-state model for the regulation of telomerase by TERRA and hnRNPA1PMID 23935072Read ↗

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TERRA long noncoding RNA: At the interphase of telomere damage, rescue and signalingSemantic proximity Read ↗

TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome endsSemantic proximity Read ↗

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Telomerase Efficiently Elongates Highly Transcribing Telomeres in Human Cancer CellsSemantic proximity Read ↗

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The Emerging Roles of TERRA in Telomere Maintenance and Genome StabilitySemantic proximity Read ↗

TERRA and the alternative lengthening of telomeres: a dangerous affairSemantic proximity Read ↗

In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2Semantic proximity Read ↗

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