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Article

Telomerase Efficiently Elongates Highly Transcribing Telomeres in Human Cancer Cells

27 Apr 2012

Abstract excerpt

RNA polymerase II transcribes the physical ends of linear eukaryotic chromosomes into a variety of long non-coding RNA molecules including telomeric repeat-containing RNA (TERRA). Since TERRA discovery, advances have been made in the characterization of TERRA biogenesis and regulation; on the contrary its associated functions remain elusive. Most of the biological roles so far proposed for TERRA are indeed based...

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Share to Epigenetics and DNA Methylation
Share to RNA modifications and cancer
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 22558207
DOI: 10.1371/journal.pone.0035714

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Related research

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Research trail→

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Telomerase Efficiently Elongates Highly Transcribing Telomeres in Human Cancer CellsPMID 22558207Read ↗

Role of TERRA in the Regulation of Telomere LengthSemantic proximity Read ↗

TERRA and the alternative lengthening of telomeres: a dangerous affairSemantic proximity Read ↗

Expression and differential regulation of human TERRA at several chromosome endsSemantic proximity Read ↗

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cellsSemantic proximity Read ↗

The alternative lengthening of telomeres mechanism jeopardizes telomere integrity if not properly restrictedSemantic proximity Read ↗

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integritySemantic proximity Read ↗

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcriptionSemantic proximity Read ↗

TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome endsSemantic proximity Read ↗

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short TelomeresSemantic proximity Read ↗

The Emerging Roles of TERRA in Telomere Maintenance and Genome StabilitySemantic proximity Read ↗

Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivoSemantic proximity Read ↗

CpG-island promoters drive transcription of human telomeresSemantic proximity Read ↗

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