Article
Skeletal muscle-specific calpain is an intracellular Na+-dependent protease.
The Journal of biological chemistry - 23 Jul 2010
Ono Yasuko, Ojima Koichi, Torii Fukuyo, Takaya Emi, Doi Naoko, Nakagawa Kazuhiro, Hata Shoji, Abe Keiko, Sorimachi Hiroyuki
Abstract excerpt
Because intracellular [Na(+)] is kept low by Na(+)/K(+)-ATPase, Na(+) dependence is generally considered a property of extracellular enzymes. However, we found that p94/calpain 3, a skeletal-muscle-specific member of the Ca(2+)-activated intracellular "modulator proteases" that is responsible for a limb-girdle muscular dystrophy ("calpainopathy"), underwent Na(+)-dependent, but not Cs(+)-dependent, autolysis in...
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