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Article

Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance.

Neuromuscular disorders : NMD - 1 Dec 2008

Beckmann Jacques S, Spencer Melissa

Abstract excerpt

Calpain 3 is a member of the calpain family of calcium-dependent intracellular proteases. Thirteen years ago it was discovered that mutations in calpain 3 (CAPN3) result in an autosomal recessive and progressive form of limb girdle muscular dystrophy called limb girdle muscular dystrophy type 2A. While calpain 3 mRNA is expressed at high levels in muscle and appears to have some role in developmental processes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscular Dystrophies, Limb-Girdle

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Source

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Identifiers

PMID: 18974005
DOI: 10.1016/j.nmd.2008.08.005
PMCID: PMC2614824

Genes

CAPN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance.PMID 18974005Read ↗

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