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Article

[The physiological and pathological function of Ca(2 +) -dependent cysteine protease (Calpain) ].

Clinical calcium - 1 Apr 2013

Sakamoto Yoko, Akazawa Hiroshi, Komuro Issei

Abstract excerpt

Calpains are Ca(2 +) -dependent cysteine proteases. Fifteen gene products of calpains are expressed in mammals. Among them, Calpain 1 and Calpain 2 are ubiquitously expressed and have been investigated extensively. Under the physiological conditions, calpain activity is strictly regulated by endogenous inhibitory protein, Calpastatin. Calpains are activated in the various cardiovascular diseases and implicated in...

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PMID: 23545741
DOI: CliCa1304519525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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