Article
An eccentric calpain, CAPN3/p94/calpain-3.
Biochimie - 1 Mar 2016
Ono Yasuko, Ojima Koichi, Shinkai-Ouchi Fumiko, Hata Shoji, Sorimachi Hiroyuki
Abstract excerpt
Calpains are Ca(2+)-regulated proteolytic enzymes that are involved in a variety of biological phenomena. Calpains process substrates by limited proteolysis to modulate various protein functions in the cell, and are thus called "modulator proteases." CAPN3, previously called p94 or calpain-3, has unique features that are not found in any of the other 14 human calpains, or even in other proteases. For instance,...
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