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Article

Autolysis, Ca2+ requirement, and heterodimer stability in m-calpain.

The Journal of biological chemistry - 25 Apr 1997

Elce J S, Hegadorn C, Arthur J S

Abstract excerpt

The roles of N-terminal autolysis of the large (80 kDa) and small (28 kDa) subunits in activation of rat m-calpain, in lowering its Ca2+ requirement, and in reducing its stability have been investigated with heterodimeric recombinant calpains containing modified subunits. Both autolysis and [Ca2+]0.5 were influenced by the ionic strength of the buffers, which accounts for the wide variations in previous reports....

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Identifiers

PMID: 9111030
DOI: 10.1074/jbc.272.17.11268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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