Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

30 Jun 2010

Abstract excerpt

Limb-girdle muscular dystrophy type 2A (LGMD2A) is a genetic disease that is caused by mutations in the calpain 3 gene (CAPN3), which encodes the skeletal muscle-specific calpain, calpain 3 (also known as p94). However, the precise mechanism by which p94 functions in the pathogenesis of this disease remains unclear. Here, using p94 knockin mice (termed herein p94KI mice) in which endogenous p94 was replaced with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Calpain Protease Function and Regulation
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20592470
DOI: 10.1172/jci40658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophyPMID 20592470Read ↗

Muscle-specific calpain-3 is phosphorylated in its unique insertion region for enrichment in a myofibril fraction.Semantic proximity Read ↗

Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance.Semantic proximity Read ↗

Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A.Semantic proximity Read ↗

Oligomer-dependent and oligomer-independent pathogenesis of muscular dystrophy-associated mutations within the penta-EF-hand domain of calpain-3.Semantic proximity Read ↗

CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)Semantic proximity Read ↗

Genetic overexpression of Serpina3n attenuates muscular dystrophy in miceSemantic proximity Read ↗

Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy).Semantic proximity Read ↗

Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice.Semantic proximity Read ↗

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease.Semantic proximity Read ↗

Pathogenity of some limb girdle muscular dystrophy mutations can result from reduced anchorage to myofibrils and altered stability of calpain 3.Semantic proximity Read ↗

Missense mutation of c.635 T > C in CAPN3 impairs muscle injury repair in a Limb-Girdel Muscular Dystropy Model.Semantic proximity Read ↗

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitroSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.