Article
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
The Journal of biological chemistry - 16 Jul 2010
Jacobs René L, Zhao Yang, Koonen Debby P Y, Sletten Torunn, Su Brian, Lingrell Susanne, Cao Guoqing, Peake David A, Kuo Ming-Shang, Proctor Spencer D, Kennedy Brian P, Dyck Jason R B, Vance Dennis E
Abstract excerpt
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study investigates whether or not hepatic PC biosynthesis is linked to diet-induced obesity. Pemt(+/+) mice fed a high fat diet for 10 weeks increased in body...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.