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Pcyt2 Deficiency Causes Age-Dependant Development of Non-Alcoholic Steatohepatitis and Insulin Resistance that Could be Attenuated with Phospho-Ethanolamine

2021-05-28

Abstract excerpt

The mechanisms of NASH development in the context of age and genetics are not fully elucidated. This study investigates the age-dependent liver defects during NASH development in mice with heterozygous deletion of Pcyt2 (ETKO), the rate limiting enzyme in phosphatidylethanolamine (PE) synthesis. Further, the therapeutic potential of Pcyt2 substrate, phosphoethanolamine (PEtn), is examined. ETKO were investigated a...

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Literature Corpus work: 99335776-90a1-51ba-a4e3-733719ded819
DOI: 10.21203/rs.3.rs-496481/v1

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