Article
A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice.
The Journal of biological chemistry - 13 Jun 2003
Noga Anna A, Vance Dennis E
Abstract excerpt
Phosphatidylethanolamine N-methyltransferase (PEMT)is involved in a secondary pathway for production of phosphatidylcholine (PC) in liver. We fed Pemt-/-mice a high fat/high cholesterol diet for 3 weeks to determine whether or not PC derived from PEMT is required for very low density lipoprotein secretion. Lipid analyses of plasma and liver indicated that male Pemt-/- mice accumulated triacylglycerols in their...
Topics
- Animal Feed
- Animals
- Apolipoproteins B
- Cholesterol
- Chromatography, Thin Layer
- Detergents
- Female
- Genotype
- Immunoblotting
- Lipid Metabolism
- Lipoproteins, HDL
- Lipoproteins, VLDL
- Liver
- Male