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Article

Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2016

van der Veen Jelske N, Lingrell Susanne, Gao Xia, Quiroga Ariel D, Takawale Abhijit, Armstrong Edward A, Yager Jerome Y, Kassiri Zamaneh, Lehner Richard, Vance Dennis E, Jacobs René L

Abstract excerpt

Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Pemt(-/-) mice are protected against high-fat diet (HFD)-induced obesity and insulin resistance; however, these mice develop nonalcoholic fatty liver disease (NAFLD). We hypothesized that peroxisomal proliferator-activated receptor-γ (PPARγ) activation by pioglitazone might stimulate...

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Identifiers

PMID: 26797396
DOI: 10.1152/ajpgi.00243.2015

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PEMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice.PMID 26797396Read ↗

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