Article
Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans.
The American journal of clinical nutrition - 1 May 2011
da Costa Kerry-Ann, Sanders Lisa M, Fischer Leslie M, Zeisel Steven H
Abstract excerpt
BACKGROUND: Choline is an essential nutrient for humans, and part of this requirement is met by endogenous synthesis catalyzed by hepatic phosphatidylethanolamine N-methyltransferase (PEMT). PEMT activity is difficult to estimate in humans because it requires a liver biopsy. Previously, we showed that mice that lack functional PEMT have dramatically reduced concentrations of docosahexaenoic acid (DHA; 22:6n-3) in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.