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Article

Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis.

Biochimica et biophysica acta - 1 Dec 2011

Niebergall Lorissa J, Jacobs René L, Chaba Todd, Vance Dennis E

Abstract excerpt

Several studies suggest that low levels of hepatic phosphatidylcholine (PC) play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis. Liver-specific elimination of CTα (LCTα(-/-)) in mice fed a chow diet decreases very-low-density lipoprotein secretion, reduces lipid efflux...

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PMID: 21745592
DOI: 10.1016/j.bbalip.2011.06.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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