Article

Phosphoethanolamine reverses aberrant DNA methylation in non-alcoholic steatohepatitis caused by Pcyt2 deficiency

2022-10-12

Abstract excerpt

<title>Abstract</title><p>Background Accumulating evidence links disruptions in phospholipid homeostasis to obesity, type 2 diabetes, and fatty liver diseases. Mice with a heterozygous ablation of the phosphatidylethanolamine (PE) synthesizing enzyme<italic>Pcyt2</italic><sup><italic>+/−</italic></sup>show reduced PE synthesis and turnover and develop an age-dependent metabolic syndrome that is characterized by im...

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Literature Corpus work: 19a88471-6e3f-5be9-a31f-a1ede54c5d0d
DOI: 10.21203/rs.3.rs-2143064/v1

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