Article
LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.
Gastroenterology - 1 Aug 2010
Morton Jennifer P, Jamieson Nigel B, Karim Saadia A, Athineos Dimitris, Ridgway Rachel A, Nixon Colin, McKay Colin J, Carter Ross, Brunton Valerie G, Frame Margaret C, Ashworth Alan, Oien Karin A, Evans T R Jeffry, Sansom Owen J
Abstract excerpt
BACKGROUND & AIMS: Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of LKB1 is an important event in sporadic pancreatic cancer. In this study, we aimed to investigate the impact of LKB1 down-regulation for pa...
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