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Article

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

29 Jan 2008

Abstract excerpt

LKB1 is a key regulator of energy homeostasis through the activation of AMP-activated protein kinase (AMPK) and is functionally linked to vascular development, cell polarity, and tumor suppression. In humans, germ line LKB1 loss-of-function mutations cause Peutz-Jeghers syndrome (PJS), which is characterized by a predisposition to gastrointestinal neoplasms marked by a high risk of pancreatic cancer. To explore...

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PMID: 18227155
DOI: 10.1128/mcb.01621-07

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