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Article

LKB1 catalytically deficient mutants enhance cyclin D1 expression.

Cancer research - 15 Jun 2007

Scott Kristine D, Nath-Sain Suchita, Agnew Meghan D, Marignani Paola A

Abstract excerpt

Mutations in the serine-threonine tumor-suppressor kinase LKB1 are responsible for Peutz-Jeghers syndrome, characterized by hamartomatous proliferation and an increased risk of developing cancer. Mutations in lkb1 have also been identified in sporadic cancers, suggesting a wider role for LKB1 in cancer that is not limited to hamartomatous polyposis syndromes. Here, we show that LKB1 catalytically deficient...

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Source

Identifiers

PMID: 17575127
DOI: 10.1158/0008-5472.CAN-07-0762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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