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Article

Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis.

Cancer research - 15 Dec 2005

Wei Chongjuan, Amos Christopher I, Stephens L Clifton, Campos Imelda, Deng Jian Min, Behringer Richard R, Rashid Asif, Frazier Marsha L

Abstract excerpt

Peutz-Jeghers syndrome (PJS) is a dominantly inherited disorder characterized by gastrointestinal hamartomatous polyps and mucocutaneous melanin pigmentation. Germ line mutations in LKB1 cause PJS. We have generated mice carrying an Lkb1 exon 2 to 8 deletion by gene targeting in embryonic stem cells. Heterozygotes develop gastric hamartomas that are histologically similar to those found in humans with PJS. LKB1...

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Identifiers

PMID: 16357136
DOI: 10.1158/0008-5472.CAN-05-0716

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