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Article

LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis

21 Dec 2015

Abstract excerpt

BACKGROUND: LKB1 is an evolutionary conserved kinase implicated in a wide range of cellular functions including inhibition of cell proliferation, regulation of cell polarity and metabolism. When Lkb1 is inactivated in the liver, glucose homeostasis is perturbed, cellular polarity is affected and cholestasis develops. Cholestasis occurs as a result from deficient bile duct development, yet how LKB1 impacts on...

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PMID: 26689699
DOI: 10.1371/journal.pone.0145400

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