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Article

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 1999

Tiainen M, Ylikorkala A, Mäkelä T P

Abstract excerpt

Germ-line mutations of LKB1 (STK11) lead to Peutz-Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of Lkb1 serine/threonine kinase activity. Therefore LKB1 has been implicated as a tumor suppressor gene, but only a few mutations in the coding exons of LKB1 have been detected in sporadic tumors. Here, we have identified...

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Identifiers

PMID: 10430928
DOI: 10.1073/pnas.96.16.9248
PMCID: PMC17765

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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