Article
HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.
Journal of virology - 1 Jun 2008
Emu Brinda, Sinclair Elizabeth, Hatano Hiroyu, Ferre April, Shacklett Barbara, Martin Jeffrey N, McCune J M, Deeks Steven G
Abstract excerpt
A rare subset of human immunodeficiency virus (HIV)-infected individuals maintains undetectable HIV RNA levels without therapy ("elite controllers"). To clarify the role of T-cell responses in mediating virus control, we compared HLA class I polymorphisms and HIV-specific T-cell responses among a large cohort of elite controllers (HIV-RNA < 75 copies/ml), "viremic" controllers (low-level viremia without therapy),...
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